Translational models for vascular cognitive impairment: a review including larger species

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Translational models for vascular cognitive impairment: a review including larger species

BACKGROUND Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, ...

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Vascular cognitive impairment (VCI) encompasses vascular dementia and is the second most common cause of dementing illness after Alzheimer's disease. The main causes of VCI are: cerebral small vessel disease; multi-infarct dementia; strategic infarct (i.e. located in a functionally-critical brain area); haemorrhage/microbleed; angiopathy (including cerebral amyloid angiopathy); severe hypoperfu...

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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.

Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific expe...

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Neuropsychiatric symptoms in Vascular Cognitive Impairment: a systematic review

Neuropsychiatric symptoms or Behavioral and Psychological Symptoms of Dementia (BPSD) are common and invariably appear at some point during the course of the disease, mediated both by cerebrovascular disease and neurodegenerative processes. Few studies have compared the profiles of BPSD in Vascular Cognitive Impairment (VCI) of different subtypes (subcortical or cortical) and clinical stages (V...

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Dementia, a syndrome of declining higher cognitive functioning, found in approximately 10 per cent of adults 65 years and older, and 50 per cent of adults older than 90 years. Alzheimer’s disease (AD) accounts for 50 to 80 per cent of all dementing illnesses. Vascular dementia comprises 15 to 20 per cent of dementia and in some clinico-pathological series is the second commonest form of dementi...

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ژورنال

عنوان ژورنال: BMC Medicine

سال: 2017

ISSN: 1741-7015

DOI: 10.1186/s12916-017-0793-9